Buccal Mucosal Metastasis of Renal Cell Carcinoma: A Case Report and Review of Literature
DOI:
https://doi.org/10.38179/ijcr.v3i1.125Keywords:
Metastatic Renal Cell Carcinoma, Buccal Mucosal Metastasis, Radiotherapy, Intraoral metastasis, Rare metastatic sitesAbstract
Background: Intraoral metastasis of RCCs are unusual, especially when it comes to buccal mucosal metastases, which are extremely rare, accounting for less than 1% of metastatic RCC. The buccal mucosal metastatic lesion from RCC poses a challenge in diagnosis and treatment. Due to their scarcity, there doesn’t exist any literature primarily concentrating on them.
Case Report: In this work, we describe the case of a 58-year-old man affected and operated on for renal cell cancer, brought to our care for the appearance of a buccal mucosal ulcer. Pathological analysis revealed a metastasis compatible with clear-cell carcinoma. Its renal origin was confirmed by immunohistochemical technique. The patient was evaluated and managed after post multidisciplinary tumor board discussion with palliative radiotherapy for local disease.
Conclusion: There should be no hurry in starting treatment for a buccal mucosal lesion, and it should be histopathologically evaluated keeping in mind a differential of metastasis from the distant primary. Multidisciplinary tumor board discussion plays an important role in such rare scenarios.
References
Znaor A, Lortet-Tieulent J, Laversanne M, Jemal A, Bray F. International variations and trends in renal cell carcinoma incidence and mortality. Eur Urol. 2015;67(3):519-530. PMID: 25449206. https://doi.org/10.1016/j.eururo.2014.10.002
Brufau BP, Cerqueda CS, Villalba LB, Izquierdo RS, González BM, Molina CN. Metastatic renal cell carcinoma: radiologic findings and assessment of response to targeted antiangiogenic therapy by using multidetector CT. Radiographics. 2013;33(6):1691-1716. PMID: 24108558. https://doi.org/10.1148/rg.336125110
Gong J, Maia MC, Dizman N, Govindarajan A, Pal SK. Metastasis in renal cell carcinoma: Biology and implications for therapy. Asian J Urol. 2016;3(4):286-292. PMID: 29264197. https://doi.org/10.1016/j.ajur.2016.08.006
Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-752.PMID: 18061527. https://doi.org/10.1016/j.oraloncology.2007.09.012
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [published correction appears in CA Cancer J Clin. 2020 Jul;70(4):313]. CA Cancer J Clin. 2018;68(6):394-424. PMID: 30207593. https://doi.org/10.3322/caac.21492
Padala SA, Barsouk A, Thandra KC, et al. Epidemiology of Renal Cell Carcinoma. World J Oncol. 2020;11(3):79-87. PMID: 32494314. https://doi.org/10.14740/wjon1279
Abraham G, Cherian T, Mahadevan P, Avinash T, George D, Manuel E. Detailed study of survival of patients with renal cell carcinoma in India. Indian J Cancer 2016; 53(4):572-4. https://doi.org/10.4103/0019-509X.204758
Jatti D, Puri G, Aravinda K, Dheer DS. An atypical metastasis of renal clear cell carcinoma to the upper lip: a case report. J Oral Maxillofac Surg. 2015;73(2):371.e1-371.e3716. PMID: 25579020. https://doi.org/10.1016/j.joms.2014.09.006
Altuntaş O, Petekkaya İ, Süslü N, Güllü İ. Renal cell carcinoma metastatic to the tongue: a case report and review of the literature. J Oral Maxillofac Surg. 2015;73(6):1227-1230. PMID: 25843819. https://doi.org/10.1016/j.joms.2014.12.031
Ganini C, Lasagna A, Ferraris E, et al. Lingual Metastasis from Renal Cell Carcinoma: A Case Report and Literature Review. Rare Tumors. August 2012:130-133. PMID: 23087797. https://doi.org/10.4081/rt.2012.e41
Lee C, Park JW, Suh JH, Nam KH, Moon KC. Histologic variations and immunohistochemical features of metastatic clear cell renal cell carcinoma. Korean J Pathol. 2013;47(5):426-432. PMID: 24255630. https://doi.org/10.4132/KoreanJPathol.2013.47.5.426
Ma F, Dai L, Wang Z, Zhou L, Niu Y, Jiang N. Evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies [published correction appears in Oncotarget. 2018 Jun 26;9(49):29285]. Oncotarget. 2016;7(29):46528-46535. PMID: 27341023. https://doi.org/10.18632/oncotarget.10225
Liu Y, Vargo RJ, Bilodeau EA. Analytic survey of 57 cases of oral metastases. J Oral Pathol Med. 2018;47(3):275-280. PMID: 29283437. https://doi.org/10.1111/jop.12672
Thrasher JB, Paulson DF. Prognostic factors in renal cancer. UrolClin North Am. 1993;20(2):247-262. PMID: 8493748.
Grange C, Tapparo M, Collino F, et al. Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res. 2011;71(15):5346-5356. PMID: 21670082. https://doi.org/10.1158/0008-5472.CAN-11-0241
Makos CP, Psomaderis K. A literature review in renal carcinoma metastasis to the oral mucosa and a new report of an epulis-like metastasis. J Oral Maxillofac Surg. 2009;67(3):653-660.PMID: 19231796. https://doi.org/10.1016/j.joms.2008.10.006
van der Waal RI, Buter J, van der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg. 2003;41(1):3-6. PMID: 12576032. https://doi.org/10.1016/s0266-4356(02)00301-7
Flanigan RC, Salmon SE, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 2001;345(23):1655-1659.PMID: 11759643. https://doi.org/10.1056/NEJMoa003013.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International Journal of Clinical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
